Glyciphage SR 1gm Tablet is a medication used for the management of type 2 diabetes mellitus. It contains Metformin Hydrochloride as its active ingredient. The "SR" in the name stands for "sustained release," indicating that the tablet is formulated to release the medication gradually, providing a prolonged therapeutic effect.

Active Ingredients:

Metformin Hydrochloride (1000mg): A biguanide class of antidiabetic agent that helps in controlling blood glucose levels.
Uses:
Glyciphage SR 1gm Tablet is primarily used for:

Type 2 Diabetes Mellitus: To manage blood glucose levels in patients with type 2 diabetes, often in combination with diet and exercise.
Mechanism of Action:

• Reduces Hepatic Glucose Production: Metformin decreases the production of glucose by the liver, helping to lower blood sugar levels.
• Improves Insulin Sensitivity: Enhances the body’s sensitivity to insulin, facilitating better glucose uptake by cells.
• Decreases Intestinal Glucose Absorption: Lowers the amount of glucose absorbed from the digestive tract.Advantages of Sustained Release (SR) Formulation:
• Steady Release: Provides a consistent release of medication, helping to maintain stable blood glucose levels throughout the day.
• Reduced Gastrointestinal Side Effects: May decrease the risk of gastrointestinal side effects such as nausea and diarrhea, which are often associated with immediate-release formulations.

Common Side Effects:

• Gastrointestinal issues (nausea, vomiting, diarrhea, abdominal discomfort)
• Risk of lactic acidosis (rare but serious condition, particularly in individuals with renal impairment or other contraindications)
• Weight loss or weight neutrality
• Vitamin B12 deficiency (with long-term use)

Precautions:

• Renal Function Monitoring: Should be used with caution in patients with impaired kidney function. Regular monitoring of renal function is recommended.
• Contraindications: Not recommended for individuals with severe renal disease or metabolic acidosis.
• Lactic Acidosis Risk: Although rare, lactic acidosis is a serious condition requiring immediate medical attention, especially in cases of dehydration or severe infection.

Dosage and Administration:

Dosage: The dosage of Glyciphage SR 1gm Tablet is determined by the healthcare provider based on the patient’s medical condition and response to treatment. It is generally started at a lower dose and gradually increased.
Administration: Typically taken with meals to minimize gastrointestinal side effects and improve absorption. The tablet should be swallowed whole, without crushing or chewing.